Biology and Diagnosis Committee (B&D)
Chair:
 |
Jan Trka since 2013, 2nd term |
Major activities
As an initiative within the EU-funded FP7 project ENCCA, consensus recommendations for diagnostic approaches to leukemias from a European viewpoint were developed. They are based on surveys of the groups participating to the AIEOP-BFM ALL 2009 study, a 7-country-based international frontline treatment trial on acute lymphoblastic leukemia (ALL) in children and adolescents, a survey of the work group DCOG Molecular Research of the Dutch Childhood Oncology Group, and the Biology & Diagnosis Committee of the International BFM Study Group.
Common guidelines for diagnostic approaches to leukemias![[PDF]](/images/pdf.gif)
Meetings
Links
Publications
(highly selected, representing collaborative research only)
Conter V, Bartram CR, Valsecchi MG, Schrauder A, Panzer-Grümayer R, Möricke A, Aricò M, Zimmermann M, Mann G, De Rossi G, Stanulla M, Locatelli F, Basso G, Niggli F, Barisone E, Henze G, Ludwig WD, Haas OA, Cazzaniga G, Koehler R, Silvestri D, Bradtke J, Parasole R, Beier R, van Dongen JJ, Biondi A, Schrappe M. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood, 2010. 115(16):3206-14.
Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, Trka J, Ben Abdelali R, Macintyre E, De Braekeleer E, De Braekeleer M, Delabesse E, de Oliveira MP, Cavé H, Clappier E, van Dongen JJ, Balgobind BV, van den Heuvel-Eibrink MM, Beverloo HB, Panzer-Grümayer R, Teigler-Schlegel A, Harbott J, Kjeldsen E, Schnittger S, Koehl U, Gruhn B, Heidenreich O, Chan LC, Yip SF, Krzywinski M, Eckert C, Möricke A, Schrappe M, Alonso CN, Schäfer BW, Krauter J, Lee DA, Zur Stadt U, Te Kronnie G, Sutton R, Izraeli S, Trakhtenbrot L, Lo Nigro L, Tsaur G, Fechina L, Szczepanski T, Strehl S, Ilencikova D, Molkentin M, Burmeister T, Dingermann T, Klingebiel T, Marschalek R. New insights to the MLL recombinome of acute leukemias. Leukemia, 2009. 23(8):1490-9.
Bonapace, L., B.C. Bornhauser, M. Schmitz, G. Cario, U. Ziegler, F.K. Niggli, B.W. Schafer, M. Schrappe, M. Stanulla, and J.P. Bourquin.Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest, 2010.
Balgobind, B.V., S.C. Raimondi, J. Harbott, M. Zimmermann, T.A. Alonzo, A. Auvrignon, H.B. Beverloo, M. Chang, U. Creutzig, M.N. Dworzak, E. Forestier, B. Gibson, H. Hasle, C.J. Harrison, N.A. Heerema, G.J. Kaspers, A. Leszl, N. Litvinko, L.L. Nigro, A. Morimoto, C. Perot, R. Pieters, D. Reinhardt, J.E. Rubnitz, F.O. Smith, J. Stary, I. Stasevich, S. Strehl, T. Taga, D. Tomizawa, D. Webb, Z. Zemanova, C.M. Zwaan, and M.M. van den Heuvel-Eibrink. Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood, 2009. 114(12): p. 2489-96.
Basso, G., M. Veltroni, M.G. Valsecchi, M.N. Dworzak, R. Ratei, D. Silvestri, A. Benetello, B. Buldini, O. Maglia, G. Masera, V. Conter, M. Arico, A. Biondi, and G. Gaipa. Risk of relapse of childhood acute lymphoblastic leukemia is predicted by flow cytometric measurement of residual disease on day 15 bone marrow. J Clin Oncol, 2009. 27(31): p. 5168-74.
Bruggemann, M., A. Schrauder, T. Raff, H. Pfeifer, M. Dworzak, O.G. Ottmann, V. Asnafi, A. Baruchel, R. Bassan, Y. Benoit, A. Biondi, H. Cave, H. Dombret, A.K. Fielding, R. Foa, N. Gokbuget, A.H. Goldstone, N. Goulden, G. Henze, D. Hoelzer, G.E. Janka-Schaub, E.A. Macintyre, R. Pieters, A. Rambaldi, J.M. Ribera, K. Schmiegelow, O. Spinelli, J. Stary, A. von Stackelberg, M. Kneba, M. Schrappe, and J.J. van Dongen. Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. Leukemia, 2009.
Coustan-Smith, E., C.G. Mullighan, M. Onciu, F.G. Behm, S.C. Raimondi, D. Pei, C. Cheng, X. Su, J.E. Rubnitz, G. Basso, A. Biondi, C.H. Pui, J.R. Downing, and D. Campana. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol, 2009. 10(2): p. 147-56.
Den Boer, M.L., M. van Slegtenhorst, R.X. De Menezes, M.H. Cheok, J.G. Buijs-Gladdines, S.T. Peters, L.J. Van Zutven, H.B. Beverloo, P.J. Van der Spek, G. Escherich, M.A. Horstmann, G.E. Janka-Schaub, W.A. Kamps, W.E. Evans, and R. Pieters. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol, 2009. 10(2): p. 125-34.
Gefen, N., V. Binder, M. Zaliova, Y. Linka, M. Morrow, A. Novosel, L. Edry, L. Hertzberg, N. Shomron, O. Williams, J. Trka, A. Borkhardt, and S. Izraeli. Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53. Leukemia, 2010. 24(1): p. 89-96.
Hertzberg, L., E. Vendramini, I. Ganmore, G. Cazzaniga, M. Schmitz, J. Chalker, R. Shiloh, I. Iacobucci, C. Shochat, S. Zeligson, G. Cario, M. Stanulla, S. Strehl, L.J. Russell, C.J. Harrison, B. Bornhauser, A. Yoda, G. Rechavi, D. Bercovich, A. Borkhardt, H. Kempski, G. Te Kronnie, J.P. Bourquin, E. Domany, and S. Izraeli. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. Blood, 2010. 115(5): p. 1006-17.
Coustan-Smith, E., C.G. Mullighan, M. Onciu, F.G. Behm, S.C. Raimondi, D. Pei, C. Cheng, X. Su, J.E. Rubnitz, G. Basso, A. Biondi, C.H. Pui, J.R. Downing, and D. Campana. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol, 2009. 10(2): p. 147-56.
Hollink, I.H., M.M. van den Heuvel-Eibrink, M. Zimmermann, B.V. Balgobind, S.T. Arentsen-Peters, M. Alders, A. Willasch, G.J. Kaspers, J. Trka, A. Baruchel, S.S. de Graaf, U. Creutzig, R. Pieters, D. Reinhardt, and C.M. Zwaan Clinical relevance of Wilms' tumor 1 gene mutations in childhood acute myeloid leukemia. Blood, 2009.
Klusmann, J.H., Z. Li, K. Bohmer, A. Maroz, M.L. Koch, S. Emmrich, F.J. Godinho, S.H. Orkin, and D. Reinhardt.miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev, 2010. 24(5): p. 478-90.
Mejstrikova, E., E. Fronkova, T. Kalina, M. Omelka, D. Batinic, K. Dubravcic, K. Pospisilova, M. Vaskova, D. Luria, S.H. Cheng, M. Ng, Y. Leung, J. Kappelmayer, F. Kiss, S. Izraeli, B. Stark, M. Schrappe, J. Trka, J. Stary, and O. Hrusak. Detection of residual B precursor lymphoblastic leukemia by uniform gating flow cytometry. Pediatr Blood Cancer, 2010. 54(1): p. 62-70.
Meyer, C., E. Kowarz, J. Hofmann, A. Renneville, J. Zuna, J. Trka, R. Ben Abdelali, E. Macintyre, E. De Braekeleer, M. De Braekeleer, E. Delabesse, M.P. de Oliveira, H. Cave, E. Clappier, J.J. van Dongen, B.V. Balgobind, M.M. van den Heuvel-Eibrink, H.B. Beverloo, R. Panzer-Grumayer, A. Teigler-Schlegel, J. Harbott, E. Kjeldsen, S. Schnittger, U. Koehl, B. Gruhn, O. Heidenreich, L.C. Chan, S.F. Yip, M. Krzywinski, C. Eckert, A. Moricke, M. Schrappe, C.N. Alonso, B.W. Schafer, J. Krauter, D.A. Lee, U. Zur Stadt, G. Te Kronnie, R. Sutton, S. Izraeli, L. Trakhtenbrot, L. Lo Nigro, G. Tsaur, L. Fechina, T. Szczepanski, S. Strehl, D. Ilencikova, M. Molkentin, T. Burmeister, T. Dingermann, T. Klingebiel, and R. Marschalek. New insights to the MLL recombinome of acute leukemias. Leukemia, 2009.
Prasad, R.B., F.J. Hosking, J. Vijayakrishnan, E. Papaemmanuil, R. Kohler, M.F. Greaves, E. Sheridan, A. Gast, S.E. Kinsey, T. Lightfoot, E. Roman, G.M. Taylor, K. Pritchard-Jones, M. Stanulla, M. Schrappe, C.R. Bartram, R.S. Houlston, R. Kumar, and K. Hemminki. Verification of the susceptibility loci on 7p12.2, 10q21.2 and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. Blood, 2009.
Real, P.J., V. Tosello, T. Palomero, M. Castillo, E. Hernando, E. de Stanchina, M.L. Sulis, K. Barnes, C. Sawai, I. Homminga, J. Meijerink, I. Aifantis, G. Basso, C. Cordon-Cardo, W. Ai, and A. Ferrando. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med, 2009. 15(1): p. 50-8.
Remke, M., S. Pfister, C. Kox, G. Toedt, N. Becker, A. Benner, W. Werft, S. Breit, S. Liu, F. Engel, A. Wittmann, M. Zimmermann, M. Stanulla, M. Schrappe, W.D. Ludwig, C.R. Bartram, B. Radlwimmer, M.U. Muckenthaler, P. Lichter, and A.E. Kulozik. High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Blood, 2009. 114(5): p. 1053-62.
Coustan-Smith, E., C.G. Mullighan, M. Onciu, F.G. Behm, S.C. Raimondi, D. Pei, C. Cheng, X. Su, J.E. Rubnitz, G. Basso, A. Biondi, C.H. Pui, J.R. Downing, and D. Campana. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol, 2009. 10(2): p. 147-56.
Russell, L.J., M. Capasso, I. Vater, T. Akasaka, O.A. Bernard, M.J. Calasanz, T. Chandrasekaran, E. Chapiro, S. Gesk, M. Griffiths, D.S. Guttery, C. Haferlach, L. Harder, O. Heidenreich, J. Irving, L. Kearney, F. Nguyen-Khac, L. Machado, L. Minto, A. Majid, A.V. Moorman, H. Morrison, V. Rand, J.C. Strefford, C. Schwab, H. Tonnies, M.J. Dyer, R. Siebert, and C.J. Harrison. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood, 2009. 114(13): p. 2688-98.
Scharn, N., M. Ballmaier, K. Reinhardt, S. Ehlers, M. Zimmermann, K. Welte, D. Reinhardt, and M. Germeshausen CSF3R mutations in paediatric acute myeloid leukaemia. Br J Haematol, 2009. 144(1): p. 140-2.
Stanulla, M., E. Schaeffeler, A. Moricke, S.A. Coulthard, G. Cario, A. Schrauder, P. Kaatsch, M. Dordelmann, K. Welte, M. Zimmermann, A. Reiter, M. Eichelbaum, H. Riehm, M. Schrappe, and M. Schwab. Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols. Blood, 2009. 114(7): p. 1314-8.
Trentin, L., M. Giordan, T. Dingermann, G. Basso, G. Te Kronnie, and R. Marschalek. Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients. Eur J Haematol, 2009. 83(5): p. 406-19.
Van der Velden, V.H., L. Corral, M.G. Valsecchi, M.W. Jansen, P. De Lorenzo, G. Cazzaniga, E.R. Panzer-Grumayer, M. Schrappe, A. Schrauder, C. Meyer, R. Marschalek, L.L. Nigro, M. Metzler, G. Basso, G. Mann, M.L. Den Boer, A. Biondi, R. Pieters, and J.J. Van Dongen. Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol. Leukemia, 2009. 23(6): p. 1073-9.
Willasch, A.M., B. Gruhn, T. Coliva, M. Kalinova, G. Schneider, H. Kreyenberg, D. Steinbach, G. Weber, I.H. Hollink, C.M. Zwaan, A. Biondi, V.H. van der Velden, D. Reinhardt, G. Cazzaniga, P. Bader, and J. Trka. Standardization of WT1 mRNA quantitation for minimal residual disease monitoring in childhood AML and implications of WT1 gene mutations: a European multicenter study. Leukemia, 2009. 23(8): p. 1472-9.
Bercovich D, Ganmore I, Scott LM, Wainreb G, Birger Y, Elimelech A, Shochat C, Cazzaniga G, Biondi A, Basso G, Cario G, Schrappe M, Stanulla M, Strehl S, Haas OA, Mann G, Binder V, Borkhardt A, Kempski H, Trka J, Bielorei B, Avigad S, Stark B, Smith O, Dastugue N, Bourquin JP, Tal NB, Green AR, Izraeli S. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet, 2008. 25;372(9648):1484-92.
Forestier E, Izraeli S, Beverloo B, Haas O, Pession A, Michalová K, Stark B, Harrison CJ, Teigler-Schlegel A, Johansson B. Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study. Blood, 2008. 1;111(3):1575-83.